Yes, Magento 2 Payment Methods can work with multi-store setups. Each store or website can have its own payment options. Admins can set different gateways for each store based on currency, location, or policies. Magento 2 Payment Methods show only the relevant options to customers at checkout. Testing each store’s payment flow helps avoid errors. Payment methods in Magento 2 make multi-store management easier. They ensure smooth and secure transactions. This improves customer experience and supports global sales efficiently.